Ginsenoside Rh3 (GRh3) induces ferroptotic cell death in CRC by promoting iron-mediated lipid peroxidation through the Signal Transducer and Activator of Transcription 3 (STAT3)/p53/Nuclear factor erythroid 2–related factor 2 (NRF2) signaling axis. Here, STAT3 is linked to colorectal carcinoma.