SLC7A5 and colorectal carcinoma: Wnt/β-catenin (ubiquitously activated in CRC) likewise engages metabolic control: for example, β-catenin-driven c-Myc upregulates amino acid transporters (SLC1A5, SLC7A5/LAT1) and enzymes (GLS), linking Wnt activity to increased amino acid uptake and glutaminolysis.