Based on existing literature, we speculate that obesity-induced increase of inflammatory factors in adipose tissue (such as macrophage, TNF-α and IL-6) and systemic inflammatory markers (such as CRP and NLR) (42) may provide a pro-inflammatory microenvironment for WT and participate in the pathogenesis of WT. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.