CRLS1 and neoplasm: Our results demonstrate that WiT49 and WT-CLS1 incubated with TGX-221 exhibited significantly enhanced susceptibility to NK cell-mediated cytotoxicity, resulting in reduced viability compared to untreated tumor cells, when co-cultured with NK cells across effector-to-target ratios of 1:1 and 5:1 (Figure 4N).