KLF4 and meningioma: While NF2 gene inactivation has long been recognized as a key driver of meningioma tumorigenesis (10, 11), more recent studies have identified non-NF2 alterations, particularly those involving the TRAKLS genes (TRAF7, AKT1, KLF4, SMO), as well as other genetic changes not otherwise classified (12, 13).