Restricting analyses to 5–20 years of follow-up, five proteins were FDR-significantly associated with ALS risk: SECTM1, CA3, THAP4, KLHL41, and SLC26A7 (all HR>1.30, p≤2.77×10−5; Table 1, Figure 2A, Supplementary Figure 1). This evidence concerns the gene THAP4 and amyotrophic lateral sclerosis.