Additionally, Gremlin 1 is an insulin antagonist with elevated levels in type 2 diabetes [83], and has been linked to bone morphogenetic proteins (BMPs) signaling imbalance, which accelerates tumor cell proliferation [84], and is associated with inflammatory processes independently of BMPs [85, 86], SCG5 encodes secretogranin V (also named 7B2 protein or SGNE1), an essential neuroendocrine signaling molecule that plays a role in cellular proliferation [87, 88]. Here, INS is linked to type 2 diabetes mellitus.