TGFB1 and fibrosis: To assess whether this trend translated into the tissue microenvironment, the distribution of the cytokines was co-detected and analyzed by qIHC in synovial tissues from patients in both fibrosis groups (Figures 2B, 2C), showing mean ± SEM signals of 76,180 ± 4,888 and 124,837 ± 8,740 arbitrary light units (ALU) for IL-11 (p < 0.0001) and TGF-β1 (p = 0.006), respectively, in the high fibrosis group compared to 39,840 ± 5,794 and 80,878 ± 6,692 ALU in the low fibrosis synovium (Figure 2D).