For G6PD-deficient patients, alternative treatments like high-dose ascorbic acid, hyperbaric oxygen, or exchange transfusion may be appropriate [11]. Although rare, methylene blue can cause side effects such as serotonin syndrome (especially in those on SSRIs), hemolysis, and a blue-green discoloration of urine or skin [6]. Supportive care during nitrite poisoning remains crucial. This evidence concerns the gene G6PD and serotonin syndrome.