The remaining 83 patients (65.4%) did not undergo biopsy: 13 normalized their PSA on repeat testing, 37 were diagnosed clinically with BPH, eight had other benign causes (e.g., urinary tract infection (UTI), prostatitis), 12 declined biopsy, and 13 were lost to follow-up. This evidence concerns the gene KLK3 and male reproductive organ cancer.