Many case reports and series have documented the presence of serum myelin oligodendrocyte glycoprotein (MOG)-IgG in some patients with AQP4-IgG-seronegative NMOSD [4]. Later, it became clear that these antibodies were also detectable among patients with acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis (ON), and autoimmune encephalitis [5]. The full clinical spectrum of MOG antibody-associated disease (MOGAD) is yet to be discovered. The gene discussed is AQP4; the disease is acute disseminated encephalomyelitis.