Analysis of all dialysis-induced cognitive decline cases revealed that the area under the ROC curve for α-klotho, FGF-23, IL-6, TNF-α, BDNF, BMI, and calcium were 0.58, 0.55, 0.58, 0.59, 0.70, 0.64, and 0.62, respectively (Figure 2). The gene discussed is TNF; the disease is Mental deterioration.