In the skeletal muscles of older adults with sarcopenia, mTORC1 may exhibit hyperactivated and reduce protein synthesis, impair mitophagy, and disrupt mitochondrial biogenesis (30), suggesting that intermittent activation of mTOR (e.g., exercise stimulation) rather than overactivation positively regulates mitochondrial biogenesis in skeletal muscle. This evidence concerns the gene MTOR and sarcopenia.