(11), in their review, report that in Alzheimer’s disease models, CBD’s neuroprotective effects may involve activation of peroxisome proliferator-activated receptor gamma (PPAR-γ) and inhibition of Nuclear Factor-Kappa B (NF-κB) - a key regulator of neuroinflammation although this mechanism has not yet been confirmed in non-Alzheimer’s aging models. The gene discussed is PPARG; the disease is early-onset autosomal dominant Alzheimer disease.