And fucoidan alleviates hyperuricemia via dual inhibition of uric acid production (XOD/ADA suppression) and promotion of excretion (ABCG2 upregulation/GLUT9 downregulation), while restoring gut microbiota diversity and enrichment of beneficial taxa, offering a therapeutic alternative for drug-intolerant patients (Wang et al., 2025). Here, SLC2A9 is linked to hyperuricemia.