PTGS2 and Stroke: Lipid metabolism analysis reveals a bidirectional imbalance in fat mobilization after stroke: the levels of proinflammatory mediators arachidonic acid and its derivative epoxyeicosatrienoic acid (Ato et al., 2020) are significantly upregulated, and the prostaglandin E2 (PGE2) generated by arachidonic acid metabolism through cyclooxygenase-2 (COX-2) increases simultaneously (Kursun et al., 2022).