CTSB and coronary artery disorder: Based on the result that TST and SYNCRIP were co-expressed with macrophage M0 and CD8 T cells, respectively, we hypothesize that the TST-CTSB splicing event co-expression pair may affect changes in the peripheral blood macrophage M0 cell ratio in CAD patients, and that the SYNCRIP-CTSB splicing event co-expression pair may affect changes in the peripheral blood CD8 T-cell ratio in CAD patients, which may potentially exacerbate the occurrence of CAD disease.