Power calculations indicated that only the EAS and EUR cohorts in GP2 had an 80% power to detect an association with an OR > 2.0 and a p-value < 0.05 (Supplementary Table 3), while the AMP-PD, UKB, and AOU cohorts were underpowered for association analysis of the LRRK2 p.A419V variant. This evidence concerns the gene LRRK2 and Parkinson disease.