Pathogenic variants in the LRRK2 gene, including p.R1067Q, p.N1437H, p.R1441G/C/H, p.Y1699C, p.G2019S and p.I2020T, are known to cause Mendelian forms of Parkinson’s disease (PD), and several were also identified as risk variants through genome-wide association studies (GWAS) and case-control analyses1–4. The gene discussed is LRRK2; the disease is Parkinson disease.