Analysis of LRRK2 p.A419V carrier status and AAO in the GP2 EAS PD group (n=73 carriers, AAO 50.3 ± 12.6 years vs. n=2292 non-carriers, AAO 53.4 ± 12.7 years) (Table 3a), revealed an association with an earlier onset of PD by approximately 3 years (β = −3.02 years; SE = 1.49; p = 0.043) after adjusting for sex and 5 PCs (Figure 1). This evidence concerns the gene LRRK2 and Parkinson disease.