LRRK2 and Parkinson disease: We investigated the genetic association between the LRRK2 p.A419V variant and PD risk and AAO, leveraging data across several cohorts, including the multi-ancestry GP2, AMP-PD, UKB, AOU cohorts, an EAS exome dataset and a Japanese dataset, totaling 40,287 PD cases and 168,681 controls.