LRRK2 and Parkinson disease: As this variant is very rare in Europeans and in Central Europeans55 and its association with PD has not been reported in individuals of EUR ancestry despite multiple GWAS and LRRK2 studies4,14,21,56, we postulate that the association in our study may be an artefact due to inheritance of the LRRK2 p.A419V variant from the EAS/CAS chromosomal regions in these individuals.