APOE and dementia: The greater late-life dementia risk in females highlights the importance of sex-specific prevention and care strategies, particularly as age, APOE ε4 status, and cardiovascular risk appear to affect females differently.44 Biological factors, including gene expression and biomarker profiles, and sociocultural influences like healthcare access and caregiving roles, may also play a role.44 Recent evidence of more aggressive tau pathology in females45 further supports the need for sex-stratified approaches in aging and dementia research.