IGHE and childhood onset asthma: Two of the replicating CpGs, cg18254848 and cg26724455, have previously been associated with allergic airway inflammation and childhood asthma: cg18254848, located in the CLC gene, has been associated in whole-blood DNAm data with IgE levels, allergic asthma, and increased FeNO46; cg26724455, located in VTI1A, has been reported as differentially methylated in nasal epithelial cells from children with asthma and high FeNO47.