Inspecting the top 100 most informative CpGs of our stratification model revealed heavily weighted CpGs in genes implicated in asthma pathogenesis and regulation of airway inflammation and remodeling (STAT3, RASSF1, MEOX1)35–37, bronchodilator response (DDX54)38, and asthma severity and lung function (ALDH2)39,40 (Supplementary Table S2). Here, STAT3 is linked to asthma.