SLFN14 and Thrombocytopenia: These include Shwachman-Diamond syndrome affecting neutrophils, caused by a mutated ribosome biogenesis factor 36, Diamond Blackfan Anemia caused by mutations in ~20 ribosomal proteins that causes selective defects in erythroid progenitors 38, specific thrombocytopenia caused by mutation in SLFN14 that causes defects in rRNA regulation which affects platelets 33.