MPL and autoimmune thrombocytopenic purpura: At present, general supportive care with a combination of treatments, including corticosteroids, IVIg, and platelet transfusion has been recommended for a more effective and rapid increase of platelet count for treatment of life-threatening hemorrhage due to ITP, and in the absence of significant response, the early addition of a thrombopoietin receptor agonists (TPO-Ras) should also be considered (Provan et al., 2019).