Proteomics analysis showed EMT, bile acid metabolism, oxidative phosphorylation, and the signaling pathways of IL-2-STAT5, VEGF, PPAR, mTORC1, as well as TNF-α signaling via NF-κB, enriched by the identified 144 DEPs, may play important roles in PCOS evolvement. This evidence concerns the gene NFKB1 and polycystic ovary syndrome.