YTHDC1 and neoplasm: CircRNAs themselves have been implicated in oncogenic processes in RMS (Rossi et al., 2021), and the study by Dattilo and colleagues provides important mechanistic insights by demonstrating that YTHDC1 and DDX5 act cooperatively to drive the biogenesis of tumor-promoting circRNAs in this context (Dattilo et al., 2023).