CTSB and HIV infectious disease: Finally, our data showing dysregulated lysosomal positioning following HIV infection in microglia and associated lysosomal exocytosis, indicated by an increase in extracellular cathepsin B, suggest that lysosomal release may be involved in the propagation of a neuroinflammatory cascade in PLWH either as a legacy effect produced during acute infection or as a result of residual viral protein levels or low-level viral replication that may continue to occur despite ART.