SMARCA4 deficient lung cancers were also shown to up-regulate oxidative phosphorylation through activation of PGC1α63; however, PGC1α and MITF did not have detectable expression in SCC1 cells even after ACTL6A knockdown (see RNA-seq dataset), suggesting other transcriptional mediators may be at play. This evidence concerns the gene SMARCA4 and lung carcinoma.