Furthermore, we identified upregulation of genes such as THBS4, DENND4A, PKIG, LEPR, CD248, and PLEKHA2, all of which have been implicated in key oncogenic processes, including angiogenesis, cell migration, invasion, extracellular matrix remodeling, activation of cancer associated fibroblast and tumor progression. The gene discussed is DENND4A; the disease is neoplasm.