Notably, the strongest overlap was observed between genes upregulated in skin tumors versus TME and those upregulated in eye tumors versus TME, with 41% of the 2,192 unique differentially expressed genes (DEGs) shared, highlighting the broad transcriptional programs activated by GNAQQ209L expression, tp53 loss, and ptena/b loss (Figure 3C). Here, TP53 is linked to skin neoplasm.