Together, our findings demonstrate that both TEAZ-Skin strategies are sufficient to induce GNAQ-driven melanoma, with strategy B demonstrating reduced tumor latency compared to strategy A. Notably, TEAZ-Skin accelerates melanoma onset relative to transgenic models;34 while tumors in transgenic Tg(mitfa:GNAQQ209L); tp53−/− zebrafish typically arise 200–400 days post-fertilization,34 TEAZ-Skin induces UM tumors by approximately 100 days in wild-type zebrafish. This evidence concerns the gene MITF and melanoma.