We predicted that by analyzing primary tumors, the transcriptional signature of the origin cell will be retained and can be identified by overlapping gene signatures identified in the embryonic melanocyte lineage.30 Interestingly, while the expression of mitfa was significantly higher in GNAQ-positive tumors, the expression of pigmentation genes; including tyrp1b, dct, scl45a2, sox10 and pmela were significantly higher in BRAF-positive melanoma (Figure S16). Here, BRAF is linked to melanoma.