APC and ovarian carcinoma: Some well-established nLTR-derived examples include de novo Alu insertions into BRCA1 and BRCA2, which predispose carriers to hereditary breast and ovarian cancers (Batzer and Deininger 2002; Teugels et al. 2005), and germline L1 insertions into the APC TSG, which underlie familial adenomatous polyposis and increase colorectal cancer risk (Miki et al. 1992).