Many of the genes whose expression levels are affected, like Rab family members (Bellucci et al., 2022, Bonet-Ponce and Cookson, 2019, Alessi and Pfeffer, 2024) and SNCA (Singleton et al., 2003, Dauer and Przedborski, 2003, Polymeropoulos et al., 1997) itself are linked to PD, as well as RNA binding proteins, such as TARDBP/TDP-43 and FUS (Mackenzie et al., 2010, Neumann et al., 2006, Hewitt et al., 2010, Moens et al., 2025) which have been linked to ALS (Supplemental Table 3). This evidence concerns the gene SNCA and Parkinson disease.