Since FOXA2 plays a role in the survival and function of dopamine neurons (Kittappa et al., 2007, Oh et al., 2016, Domanskyi et al., 2014) the reduced expression or function of FOXA2 gene in the DNAJC6 FS mutant may contribute to the neurodegeneration in Parkinson's disease. The gene discussed is FOXA2; the disease is Parkinson disease.