PRKN and Parkinson disease: Multiple clonally independent isogenic stem cell lines were generated carrying common familial PD mutations including PRKN (X3DEL), SNCA (A30P and A53T), LRRK2 (G2019S), PINK1 (Q129X), DNAJC6 (FS), FBXO7 (FS), SYNJ1 (R258Q), PARK7 (X1_5DEL), VPS13C (W395C), ATP13A2 (FS) and GBA1 (IVS2) using CRISPR Cas9 or prime editing techniques, as previously reported (Figure 1A) (Li et al., 2022b, Busquets et al., 2025).