PRKN and Parkinson disease: In our initial studies with the familial PRKN, SNCA, LRRK2, PINK1, DNAJC6, FBX7, SYNJ1, DJ1, VPS13C, ATP13A2 and GBA1 mutants, we have identified splicing pattern changes for the well-known RNA splicing factor SRRM2 and the guanine nucleotide exchange factor DOCK10 in all or many of the twelve PD mutant cell lines.