Our results linking splicing pattern alterations to PD are consistent with uncovered defects in global pre-mRNA splicing patterns discovered in other neurodegenerative diseases such as ALS (Li et al., 2021, Wang et al., 2020), SMA (Singh and Singh, 2018) and various cancers (Choi et al., 2023, Zhang and Manley, 2013, Bradley and Anczukow, 2023, Stanley and Abdel-Wahab, 2022, El Marabti and Abdel-Wahab, 2021). This evidence concerns the gene SMN1 and Parkinson disease.