In our initial studies with the familial PRKN, SNCA, LRRK2, PINK1, DNAJC6, FBX7, SYNJ1, DJ1, VPS13C, ATP13A2 and GBA1 mutants, we have identified splicing pattern changes for the well-known RNA splicing factor SRRM2 and the guanine nucleotide exchange factor DOCK10 in all or many of the twelve PD mutant cell lines. This evidence concerns the gene SNCA and Parkinson disease.