It is also clear that mutations in RNA binding protein genes or altered expression levels of RNA binding proteins, such as TDP-43 (Nussbacher et al., 2019, Kapeli et al., 2017) splicing factors and spliceosome components, such as U2AF1 and SF3B1 (Choi et al., 2023, Bradley and Anczukow, 2023, Stanley and Abdel-Wahab, 2022, El Marabti and Abdel-Wahab, 2021) play roles in neurodegeneration and cancer, respectively. This evidence concerns the gene U2AF1 and cancer.