The convergence of depression-like phenotypes in our R1441G KI+/− mice with those in the G2019S transgenic model reinforces the critical role of LRRK2 mutations in PD non-motor psychopathology, warranting deeper investigation into their shared mechanisms (e.g., dysregulated dopaminergic and/or serotonergic signalling and neuroinflammation) and potential sex-dependent developmental trajectories. The gene discussed is LRRK2; the disease is Parkinson disease.