Expanding on the multifunctional potential of BiNPs, Oztas et al. (2019) developed a novel theranostic platform using ultrasmall BiNPs (3.6 nm) conjugated with the tumor-penetrating peptide LyP-1.49 These Bi-LyP-1 NPs exhibited targeted tumor accumulation and were capable of dual-modal imaging—computed tomography (CT) and photoacoustic (PA)—due to their efficient absorption in the ionizing radiation and second near-infrared (NIR-II) spectral regions. This evidence concerns the gene PTPN22 and neoplasm.