Huang et al. (2025) recently demonstrated the immunomodulatory effects of transferrin-functionalized bismuth nanoparticles (TBNPs), synthesized using a green chemistry route.43 Designed to overcome the challenges posed by the blood–brain barrier (BBB) in glioma treatment, these protein-coated TBNPs showed enhanced biosafety and improved tumor selectivity. Here, TF is linked to glioma.