BCL11B rearrangement is observed in AUL, T-cell and myeloid (T/myeloid) MPAL, early T-precursor lymphoblastic leukaemia (ETP-ALL) and AML.21 The ICC includes BCL11B rearrangement only as a recurrent genetic abnormality in ETP-ALL. Here, BCL11B is linked to acute myeloid leukemia.