In HD, although participants showed a variable background activation (the condition including only CD8+ T cells), we observed that memory CD8+ T cells showed a higher enterotoxin type B (SEB)‐specific production of IFNγ and TNFα, along with a higher expression of the degranulation marker CD107a and cytotoxicity marker perforin (PRF), when cocultured with primed pDCs and CD141+ mDCs (Figure 3A,B). This evidence concerns the gene PRF1 and Huntington disease.