Hence, unfractionated cells from blood of HD and PLWH, as well as from HD tonsils were prestimulated with TLR‐7 and TLR‐3 agonists and then cultured with the specific antigens (SEB or HIV Gag peptides) in presence or absence of pembrolizumab for PD‐1 blockade (Table S1 and Figure S5A). Here, TLR7 is linked to Huntington disease.