FOS and early-onset autosomal dominant Alzheimer disease: For example, SNP rs2042528 (A/T) in gene CSMD1 had significant interaction signals for both all-cause dementia (P = 0.005) and Alzheimer's disease (P < 0.001), and FOS had opposite association directions with Alzheimer's disease in the two homozygous genotype groups (HR: 1.23; 95% CI: 1.07, 1.41, in individuals of TT genotype; HR: 0.80; 95% CI: 0.68, 0.94, in individuals of AA genotype) (Figure 2D).