Bridging integrator 1 (BIN1), triggering receptor expressed on myeloid cells 2 (TREM2), and zinc finger CW-type (ZCWPW1)/PWWP domain containing 1 (NYAP1) were identified in both all-cause dementia and Alzheimer's disease. The gene discussed is TREM2; the disease is early-onset autosomal dominant Alzheimer disease.