From the comparison of FOS exclusively defined by two questionnaires, interaction signals around peroxisomal biogenesis factor 26 (PEX26), EED, and CAMK2D were replicated in all-cause dementia, Alzheimer's disease, and vascular dementia outcomes, respectively (Supplemental Figure 7). This evidence concerns the gene CAMK2D and early-onset autosomal dominant Alzheimer disease.