In terms of health condition, there were no significant differences in CRP after the Is in healthy participants (MD: –0.605; 95% CI: –1.336, 0.125; I2: 68%), in those with overweight or obesity (MD: –0.025; 95% CI: –2.461, 2.411; I2: 41%) nor in those with chronic diseases (MD: –0.454; 95% CI: –1.209, 0.301; I2: 0%). This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.