GLP1R and hyperthyroidism: Potential mechanisms of hyperthyroidism include GLP-1 receptor activity in thyroid tissue in which stimulation of GLP-1 receptors expressed on thyroid cells may influence thyroid hormone synthesis or secretion, leading to transient hyperthyroidism.4,5 Thyroid function is disrupted by directly altering the hypothalamic-pituitary-thyroid axis or inducing inflammation in thyroid follicular cells, resulting in thyroiditis.