PEX5 and Zellweger spectrum disorders: Zellweger spectrum disorders (ZSDs), including archetypal Zellweger syndrome, neonatal adrenoleukodystrophy (NALD) and infantile Refsum disease (IRD), are PBDs caused by mutations in peroxin genes (PEX1, PEX2, PEX3, PEX5, PEX6, PEX10, PEX11β, PEX12, PEX13, PEX14, PEX16, PEX19 or PEX26).