The progressive demyelination observed in brains of patients with X-ALD is associated with increased VLCFAs, gliosis and increased proinflammatory cytokines (IL-15, IL-12p40, CXCL8, CCL11, CCL22, IL-4) detected in the blood, in demyelinating plaques (including increased IL-1β, TNF-α, IFN-γ), and in cerebrospinal fluid (CSF) (IL-8, IL-1ra, MCP-1, MIP-1b) of affected patients relative to controls (Lund et al., 2012; Weinhofer et al., 2023; Schlüter et al., 2012). This evidence concerns the gene CXCL8 and X-linked adrenoleukodystrophy.