• Excessive lipid peroxidation is a significant trigger for ferroptosis, while abnormal inflammatory responses can lead to iron metabolism disorders and an imbalance in redox system.• Activation of the MAPK pathway promotes the production of pro-inflammatory cytokines IL-1β and IL-6, reduces the expression of GPX4, and triggers the occurrence of neuro inflammation and ferroptosis. Here, GPX4 is linked to iron metabolism disease.