The incidences of specific all-grade AEs, including rash, cough, dizziness, fatigue, edema, transaminase elevation (AST/ALT), gastrointestinal disturbances (diarrhea, vomiting, nausea, constipation), sinus bradycardia, hematological toxicities (anemia, neutropenia), and ocular disorders, were analyzed using a random-effects meta-analysis and are summarized in Table 2. This evidence concerns the gene GPT and neutropenia.