CRC pathogenesis involves the dysregulation of multiple pivotal signaling pathways: The Wnt/β-catenin pathway promotes tumor cell proliferation and differentiation, the PI3K/AKT pathway enhances cancer cell growth, survival, and metabolic adaptation, and the RAS/RAF/MEK/ERK cascade drives cell cycle progression and aberrant proliferation. This evidence concerns the gene AKT1 and neoplasm.