TP53 and colorectal carcinoma: Apigenin (Lee et al., 2014) and kaempferol (Choi et al., 2018) were shown to induce PARP cleavage and decrease the levels of caspases −8, −9, and −3, finally promoting apoptosis in CRC cells, however, the pro-apoptotic effects of kaempferol were reversed by ROS and p53 signaling.