Deng and colleagues reported that miR-149 can inhibit the expression of EphB3 and downregulate the expression of PI3K/AKT signaling pathway, and then inhibit the function of STAT3 pathway, and ultimately induce G0/G1 stagnation in colorectal cancer cells, and inhibit the proliferation and invasion of colorectal cancer cells (Deng et al., 2021). Here, AKT1 is linked to colorectal cancer.