STAT3 and colorectal cancer: In cells such AS colorectal cancer and non-small cell lung cancer, AS-IV can dose-dependently enhance the Bax/Bcl-2 ratio and activate caspase-3, and simultaneously downregulate Mcl-1 and NF-κB by blocking the IL-6/JAK2/STAT3 axis, thereby inhibiting anti-apoptotic signals.