Therefore, considering that neuroinflammation and mTOR signaling play an central role in epileptic seizures and luteolin presents anti-inflammatory properties and targets mTOR hyperactivation but presents low bioavailability, we propose the investigation of the antiseizure and neuroprotective potential of luteolin and micronized luteolin in a PTZ-induced seizure model in zebrafish larvae with the aim of collaborate for identify new therapeutic targets and screen new drugs for the treatment of epilepsy occurring during the early stages of the life. This evidence concerns the gene MTOR and epilepsy.