This epigenetic modulation alleviates MDD-related phenotypes via suppression of the endoplasmic reticulum stress inositol-requiring enzyme 1 alpha/X-box binding protein 1 (IRE1α/XBP1) pathway, reducing ferroptosis-associated lipid peroxidation and mitochondrial dysfunction (Wang et al., 2024a). This evidence concerns the gene XBP1 and major depressive disorder.