Animal studies demonstrate that CSDS upregulates the bromodomain adjacent to zinc finger domain/SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 complex in the NAc, promoting nucleosome clustering at transcription start sites to block gene transcription, particularly suppressing BDNF expression and increasing MDD susceptibility (Sun et al., 2015). Here, BDNF is linked to major depressive disorder.