In this context, the present study aimed to evaluate the serum concentrations of netrin-1, IL-6, hs-CRP, and adiponectin in individuals with different metabolic profiles—non-obese controls, preclinical obese individuals, and clinical obese individuals with insulin resistance—to explore the association between these biomarkers, systemic inflammation, and early metabolic alterations. Here, NTN1 is linked to Insulin resistance.