While EGFR-TKI-associated ILD primarily arises from direct epithelial injury and pro-fibrotic signaling in genetically susceptible hosts (Scheffler et al., 2011; Ishigu et al., 2013), ICI-related pneumonitis stems from T-cell-mediated inflammation and dysregulated immune responses (Spagnolo et al., 2022). The gene discussed is EGFR; the disease is pneumonitis.