These subtypes include DLBCL, not otherwise specified, which serves as the default category; high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, characterized by genetic abnormalities that drive more aggressive disease; primary CNS or testicular DLBCL, defined by their location; Epstein-Barr virus-positive DLBCL, associated with chronic viral infection; and other less common site- or pathogen-specific variants [3]. This evidence concerns the gene MYC and diffuse large B-cell lymphoma.