FBC: Full blood count, LFT: Liver function test, FIT: Faecal immunochemical test, CTPA: Computed tomogram pulmonary angiography, CT TAP: Computed tomogram thorax abdomen and pelvis, MUO-MDT: Malignancy of unknown origin multidisciplinary team, MRI: Magnetic resonance imaging, CRP: C-reactive protein, ESR: Erythrocyte sedimentation rate, PET-CT: Positron emission tomography, ECHO: Echocardiograph, EF: Ejection fraction, PUO: Pyrexia of unknown origin, FFP: Fresh frozen plasma, ASM: Aggressive systemic mastocytosis. This evidence concerns the gene CRP and Fever.