Drug target MR (Figure 6) identified causal associations of serum TMEM106B level on depression (OR = 0.92, 95% CI = 0.90−0.94, p=2.04 × 10−12), stroke (OR = 0.90, 95% CI = 0.86−0.95, p=3.53 × 10−5), ischemic stroke (OR = 0.89, 95% CI = 0.85−0.94, p=5.31 × 10−5), smoking initiation (OR = 0.98, 95% CI = 0.97−1.00, p=3.71 × 10−2), hypertension (OR = 0.99, 95% CI = 0.98−1.00, p=1.50 × 10−2), and type 2 diabetes (OR = 0.92, 95% CI = 0.89−0.94, p=3.20 × 10−9). The gene discussed is TMEM106B; the disease is type 2 diabetes mellitus.