ANon-diseased VI in suboptimal health conditions (pronounced stress-provoked vasoconstriction, dry mouth syndrome, vaginal dryness, high stress sensitivity, shifted regulation of sense-receptors, shifted circadian rhythms and sleep patterns, high endothelin-1 level in blood, frequent tiredness and dizziness, anxiety and panic attacks, amongst others) [1, 4–9], and. The gene discussed is EDN1; the disease is Anxiety.