Due to the fact that the expression of angiogenesis markers differs depending on the type of tumor and the stage of its development, another team has focused on this area (Willmann et al., 2008) investigated the application of microbubbles engineered to simultaneously target VEGFR2 and αvβ3 integrin, aiming to enhance imaging signals in human ovarian cancer xenografts grown under the skin in mice. The gene discussed is KDR; the disease is neoplasm.